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Allopurinol Now Primary Medication for Gout

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When the U.S. Food and Drug Administration (FDA) limited the use of Uloric in February of 2019, allopurinol became the primary medication for the treatment of gout, which could also trigger a rise in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis (SJS/TEN).

Gout typically occurs near the base of the big toe, but it can show up in any joint: fingers, knees, ankles, elbows, and wrists.

Gout is a painful type of arthritis that affects approximately 8.3 million people in the US. It is caused by excess uric acid levels, but medications like Uloric and allopurinol can control and manage uric acid levels. When a clinical trial revealed that Uloric was linked to an increased risk of heart-related death, black-box warnings were added to the medication’s label and the FDA ordered that it no longer be considered a first-line treatment for gout, and allopurinol use increased.

SJS/TEN Connected to Allopurinol Use

Although the most common side effects of allopurinol are upset stomach, diarrhea, and drowsiness, research has found that SJS/TEN is also linked to its use. Allopurinol has been found to be among the medications most likely to cause SJS/TEN in the U.S.

Once thought to be completely separate conditions, the National Institutes of Health now considers SJS/TEN to be a continuum of the same reaction. Beginning with flu-like symptoms, SJS/TEN often progresses to blistering and peeling of the skin within a few days, and the affected area resembles a hot water burn.

Common Symptoms of SJS/TEN

Allopurinol Lawsuits Being Filed

Lawsuits are being filed by those who have developed SJS/TEN after taking allopurinol. The people bringing these cases are requesting compensation for a number of damages caused by allopurinol use and the resulting incidence of SJS/TEN, including reimbursement for medical bills, lost wages, and pain and suffering.

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